Abstract
Summary:(±) Lercanidipine hydrochloride (HCl) (Zanidip) is an antihypertensive drug structurally related to dihydropyridine calcium-entry blockers: lercanidipine is weakly basic (pK′a = 6.83 at 37°C) and highly lipophilic (log P octan-1-ol/water = 6 at 20-25°C). After oral administration of 10-20-mg
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