Abstract
Objective To investigate the effect of liver function and survival rate on allogeneic bone mesenchymal stem cells (BMSCs) transplantation through portal vein in the rat 80％ hepatectomy model.Methods Build up the edge of limit hepatectomy rat model,transplant the 5th passage (P5) allogeneic rat BMSCs marked with green fluorescent protein ( GFP),observe the effect of liver function and survival rate after allogeneic BMSCs transplantation through portal vein in the rat hepatectomy model Results Survival rate after 7 days:MSC Group 72.2％ (13/18),control Group 44.4％ (8/18),The survival rate of MSC Group was significantly higher than control Group (72.2％ vs.44.4％,P ＜0.05) ;the liver function recovery after surgery of MSC Group is better than control Group ( P ＜ 0.05 ) ; transplanted BMSCs could be deteced in recipient liver of MSC Group.Conclusion BMSCs transplanted though portal vein can promote liver function recovery and improve survival rates in rat 80％ hepatectomy model. Key words: Bone marrow mesenchymal stem cells; Liver resection; Acute liver failure; Green fluorescent protein
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