Abstract
The direct conversion of human skin cells into nerve cells is an emerging field with potential applications in regenerative medicine. This study investigates the conversion of Human Skin-Derived Progenitor Cells (hSKPs) and Human Dermal Fibroblasts (hDFs) into neural cells using specific transcription factors or molecular cocktails. A review of the literature was conducted to inform the design of a research study employing a combination of in vitro and in vivo experiments and molecular biology techniques to induce neural differentiation in skin-derived cells. The findings demonstrate that both hSKPs and hDFs can successfully differentiate into neural cells, displaying neuronal morphology and electrophysiological functionality. These studies conclude that skin cells possess significant potential for direct reprogramming into functional neurons, providing a direct approach for studying neurological diseases and developing therapeutic strategies. However, challenges regarding the efficiency and safety of the reprogramming process persist, necessitating further optimization prior to clinical application
Published Version
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