Abstract
Objective To analyze the polymorphism of exon 1 in mannose-binding lectin (MBL)gene in Zhuang population in Guangxi and to explore its relationship with the susceptibility to tuberculosis. Methods The polymorphism of exon 1 in MBL gene in 100 healthy individuals and 100 patients with tuberculosis was determined by polymerase chain reaction-restriction fragment length polymorphism to analyze the differences of mutant genotype frequency in two groups. Results There was no statistical significance on the frequency of MBL mutant allele (B allele) between healthy control group (33.3 % ) and tuberculosis group (35.1% ). Conclusions Mutation of codon 54 in MBL gene may not be the genetic risk factor of tuberculosis in Zhuang population in Guangxi. Key words: Tuberculosis; Mannose-binding lectin
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