Abstract
This study intends to discuss mechanism of miR-488-5p carried with magnetic carbon nanotubes (MAGCNTs) in restraining lymphatic metastasis in cervical cancer through induction of mTOR/P70S6K signaling pathway. Fifty female rats were randomly divided into five sets, which included control set, miR-488-5p set, empty carrier set, set of miR-488-5p carrier and inhibitor set. The MAGCNTs were prepared and characterized. Condition and quantity of lymphatic metastasis in cervical cancer, miR-488-5p expression and protein expression of factors related with mTOR/P70S6K signaling transduction pathway were observed. Quantity of lymphatic metastasis in the control set was highest, while quantity of lymphatic metastasis in the set of miR-488-5p and carrier were lowest. Expressions of miR-488-5p in of the miR-488-5p and carrier sets were highest and lowest in the control set, and mTOR/P70S6K expression was reversed. miR-488-5p was carried with multi-walled carbon nanotubes (MWCNTs) and entered into cells more rapidly. There was over expression of miR-488-5p and activity of mTOR/P70S6K signaling pathway was restrained. The information conduction was slowed down, and therefore, the lymphatic metastasis in the cervical cancer was restrained.
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