Research on dividing management on intrahepatic cholestasis during pregnancy and the pregnancy outcome

Abstract

Objective To probe the outcome of intrahepatic cholestasis during pregnancy (ICP) in patients with pregnancy after dividing management.Methods 142 patients with ICP in the perinatal period were limited to establish biochemical indexes.These patients were divided into two groups:group A with 104 mild patients (experimental group),group B with 38 severe patients (control group).The experimental group included 52 mild cases (A1) and 19 severe cases (A2).The grading diagnosis and treatment were used in group A.The patients in group A1 were expected to natural labor and vaginal trial production before 41 weeks gestation,and the patients in group A2 were treated with early intervention and planned cesarean section termination of pregnancy.The patients in Group B were treated without grading diagnosis and treatment.The personalized treatment was used in group B.The pregnancy outcome of these two groups was observed.Results Between these two groups,there were 11.3％ of low-birth weight infants,11.3％ of amniotic fluid turbidity,5.6％of neonatal asphyxia,32.4％ of cesarean delivery and 5.6％ of postpartum hemorrhage in group A; while there were 19.7％ of low birth weight infants,15.5％ of amniotic fluid turbidity,15.5％ of neonatal asphyxia,64.8％of cesarean delivery and 9.9％ of postpartum hemorrhage in group B,showing more statistical significant difference (P＜0.05).Conclusion Grading diagnosis and corresponding proper treatment to patients with ICP can improve the pregnancy outcome. Key words: Gestation; Intrahepatic cholestasis during pregnancy (ICP); Dividing management; Pregnancy outcome