Abstract
Objective To investigate the clinical value of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the treatment and therapeutic effect evaluation of patients with an exacerbation of chronic obstructive pulmonary disease. Methods The levels of serum sTREM-1, procalcitonin (PCT) and C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assay(ELISA) in 49 exacerbation of chronic obstructive pulmonary disease (COPD) subjects[acute exacerbation of chronic obstructive pulmonary disease (AECOPD) group], 49 stable COPD subjects(sCOPD group) after treatment and 49 healthy volunteers as healthy control group. The levels of sTREM-1, PCT and CRP in different groups were compared and the relationship between the level of sTREM-1 in AECOPD and sCOPD groups, and PCT, and CRP was analyzed, respectively. Results The content of sTREM-1, PCT and CRP between different groups had significant difference(P 0.05). Conclusions For guiding the treatment and curative effect evaluation of patients with AECOPD, sTREM-1 has important clinical reference value. Key words: Membrane glycoproteins/ME; Receptors, immunologic/ME; Pulmonary disease, chronic obstructive/ME
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