Research of the Genotype Association by Locus Rs7903146 of the Tcf7l2 Gene and the Risk of Abdominal Obesity Development among Young Residents of the North

Abstract

Currently, interest in studying obesity as a chronic inflammatory disease continues to grow. Despite numerous recommendations for reducing excess weight, the majority of the population does not assess the importance of this pathology for the development of serious cardiovascular diseases. Eating disorders and physical inactivity continue to prevail among the majority of the population, and especially, it is common among young people. Climatic factors also play an important role in changing fat metabolism. This is peculiar, especially to residents of the northern regions, where, under the influence of cold, lipid and carbohydrate metabolism is often disturbed, which contributes to the accumulation of abdominal fat. However, a genetic predisposition to obesity is one of the common causes of this disorder. The TCF7L2 gene (localization - 10q25.3) controls the synthesis of a transcription factor that regulates the expression of the proglucagon gene involved in carbohydrate metabolism [1]. So, the CT and TT alleles of rs7903146 of the TCF7L2 gene lead to insulin deficiency in the body. In addition, the TCF7L2 gene regulates the differentiation of adipose tissue cells [2; 3]. To study the association of rs7903146 of the TCF7L2 gene with a risk of developing abdominal obesity among young residents of the north.