Abstract
Aim of research. Depth study of polysaccharides in some little-known plant species of Asteraceae family is pressing question, considering that polysaccharides are important biologically active compounds widely used in pharmaceutical and medical practice as remedies and preventive medications. The aim of research was to determinate both quantitative content and monomeric composition of polysaccharide complexes from Asteraceae family plant species – Tagetes genus, Arnica genus, and Bellis genus.Materials and methods. Determination of polysaccharides was carried out by the precipitation reaction, using 96 % ethyl alcohol P and Fehling's solution after acid hydrolysis; quantitative content of this group of compounds was determined by gravimetric analysis. On purpose to identify the monomeric composition hydrolysis under sulfuric acid conditions was conducted. Qualitative monomeric composition of polysaccharides after hydrolysis was carried out by paper chromatography method in n-Butanol – Pyridine – Distilled water P (6:4:3) system along with saccharides reference samples.Results. Polysaccharide complexes from Tagetes erecta, Tagetes patula, Tagetes tenuifolia, Arnica montana, Arnica foliosa, wild and cultivated Bellis perennis herbs were studied. Water-soluble polysaccharides and pectin fractions were isolated from studied objects; their quantitative content and monomeric composition were determined.Conclusion. The highest amount of water-soluble polysaccharides was found in cultivated Bellis perennis herb (10,13 %), the highest amount of pectin compounds – in Tagetes tenuifolia herb (13,62 %); the lowest amount of water-soluble polysaccharides and pectin compounds was found in Arnica montana herb (4,61 %) and Tagetes patula herb (3,62 %), respectively. It was found that polysaccharide complexes from all studied species include glucose and arabinose
Highlights
котрі засновані на реакції кількісного окиснення цефадроксилу калій гідрогенпероксомоносульфатом в кислому середовищі до відповідного S-оксиду з наступним визначенням залишку окисника йодометричним методом
Одержані валідаційні характеристики відповідають критеріям прийнятності згідно ДФУ, що свідчить про можливість її впровадження в практику аналізу контрольно-аналітичних лабораторій, або використання під час здійснення постадійного контролю процесу виготовлення лікарських засобів чи контролю якості відмивки обладнання Ключові слова: цефадроксил, йодометричне титрування, калій гідрогенпероксомоносульфат, β-лактамний антибіотик, кількісне визначення, сульфоксид
Summary
Farmacevticheskaya opeka: Simptomaticheskoe lechenie systavnoj I mishechnoj boli [Pharmaceutical care: Symptomatic treatment of joint and muscle pain].Pharmacist, 12, 18–22. Modern non-steroidal anti-inflammatory drugs on the pharmaceutical market of Ukraine. Hondroprotektori v lechenii octeoartroza [Chondroprotectors in the treatment of osteoarthritis]. Doslidgennya medikamentoznogo zabezpechennya chvorih na revmatoidnij artrit [Research of medical support for the treatment of patients with rheumatoid arthritis in Ukraine]. EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis. Marketingovie issledovania farmacevticheskogo rinka preparatov, ispolzyemih mestno pri zabolevaniah oporno-dvigatelnogo apparata [Marketing research pharmaceutical market of medications used topically for diseases of the musculoskeletal apparatus]. Effectivnost‟ ecstracta martini dyshistoj (Systamar) pri osteoartritah, poyasnichnoj boli i fibromialgii: obzor assledovanij[Efficacy of the extract Harpagophytum procumbens (Sustamar) for osteoarthritis, fibromyalgia and low back pain: a review of research].
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