Abstract
Classic phytoadaptogens (Panax ginseng, Rhodiola rosea, Aralia mandshurica, Oplopanax elatus, Eleutherococcus senticosus, Leuzea carthamoides, Schisandra chinensis) have a complex protective effects, increasing the antitumor control of organisms. However, resistance to some adaptogens can develop. Therefore, the elaboration of multicomponent phytoadaptogen complexes based on the principle of a rational combination of complementary biologically active substances are relevant and scientifically significant. The use of several adaptogens in the herbal formula considers the absence of the organisms resistance. The review presents Russian and foreign studies devoted to the search for potential phytoadaptogens, as well as the development of complexes based on them. The possibility of regulating the protective systems of organism by components of phytoextracts with different points of pharmacological action has been shown. The advantages of multicomponent phytomixtures in comparison with individual adaptogens are substantiated. The many-sided experimental in vitro and in vivo investigations of Russian herbal formula are colligated. Its clinical application has been demonstrated in relation to a benign tumour, precancerous disease, advanced cancer process, and neurodegenerative pathology. The prospects of using the herbal formula preparations as a part of integrative medicine including oncological and age-related pathologies are shown.
Highlights
The elaboration of multicomponent phytoadaptogen complexes based on the principle of a rational combination of complementary biologically active substances are relevant and scientifically significant
The use of several adaptogens in the herbal formula considers the absence of the organisms resistance
The review presents Russian and foreign studies devoted to the search for potential phytoadaptogens, as well as the development of complexes based on them
Summary
Классические фитоадаптогены (женьшень настоящий, родиола розовая, аралия маньчжурская, заманиха высокая, элеутерококк колючий, левзея сафлоровидная, лимонник китайский) обладают комплексным защитным действием на организм, в том числе повышают его противоопухолевую устойчивость. Поэтому актуальными и научно значимыми являются исследования многокомпонентных фитоадаптогенных комплексов, основанных на принципе рационального сочетания взаимодополняющих по действию биологически активных веществ. Применение нескольких адаптогенов в составе одной фитоформулы позволяет воздействовать на организм, не вызывая привыкания. В обзоре представлены отечественные и зарубежные исследования, посвященные поиску потенциальных фитоадаптогенов, а также разработке комплексов на их основе. Продемонстрированы результаты его клинического применения в отношении доброкачественной опухоли, предракового заболевания, распространенного опухолевого процесса, нейродегенеративной патологии. Показана перспективность использования комплексных препаратов в составе интегративных методов терапии, в том числе онкологических и возрастных патологий.
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