Research Advances on Abnormal Secretion and Function Abnormality of Exosomes Derived from Lymphoma Cells Caused by Latent EB Virus--Review

Abstract

Abstract The Latent infection cansed by Epstein-Barr virus (EBV) closely relates with the occurrence and development of several kinds of lymphoma. Exosome (EXO) is functional bilayer membrane structural corpuscles which are secreted by cells contain proteins, lipids and nucleic acids. In recent years, researches showed that EXO play an important role in the occurrence and development of tumors. Therefore, the resenrches which compare the differences in quantity and contents of EXO secreted by cells between EBV negative lymphoma and EBV positive lymphoma and the clarify the influence of EXO on biological behaviors of lymphoma cells and immune cells have the important, significance for understanding the mechanisms related with effect of latent EBV on the occurrence and development of lymphoma by exosome pathway. This review focuses on research progress about the effect of latent EBV on amounts, contents and functions of EXO secreted by lymphoma cells.EB病毒潜伏感染致淋巴瘤细胞外泌体分泌和功能异常的研究进展.EB病毒(EBV)潜伏感染与多种淋巴系统肿瘤发生发展有着密切关系。外泌体(EXO)是细胞分泌的包含蛋白质、脂质、核酸等的功能性双层膜结构小体。近几年来有研究表明，EXO在肿瘤发生发展过程中起着重要作用，故对比EBV阴性和EBV阳性淋巴瘤细胞在EXO分泌数量与内容物方面的差异，了解EXO对淋巴瘤细胞和免疫细胞生物学行为的影响，对EBV潜伏感染通过外泌体途径影响淋巴瘤发生发展机制的研究具有重要意义。本综述重点阐述EBV潜伏感染对淋巴瘤细胞EXO分泌数量、内容物及其功能的影响.