Abstract
Human natural killer (NK) cell development is poorly understood; however, we gain important insight from cases of human primary immunodeficiency that affect the generation of mature human NK cell subsets. In this review, monogenic primary immunodeficiencies that highlight critical requirements for human NK cell development are discussed. Increased resolution in NK cell phenotyping has revealed NK cell deficiencies that affect the distribution of NK cell subsets found in peripheral blood. These, in addition to those that prevent the generation of mature NK cells, identify important requirements for the maturation and homeostasis of human NK cells. The serious and often life-threatening viral susceptibility that accompanies these highlights the nonredundant role that NK cells play in human health and disease. Human NK cell deficiency may occur in cases where NK cells are present in normal numbers but subsets are affected.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Current opinion in allergy and clinical immunology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
