Abstract
Purpose: Osteoarthritis (OA) affects 27 million people in the US and has no disease modifying treatments. Since joint injuries lead to OA, intervention at the time of injury could prevent injury-induced OA. Synovial fluid (SF) glutamate concentrations increase in arthritis. We previously found that activation of kainate (KA) and AMPA glutamate receptors (GluRs) increases interleukin-6 release and causes pain, that AMPA and KA GluRs localise to osteoarthritic bone, cartilage and synovium and that NBQX (AMPA/KA GluR antagonist) reduces knee swelling, gait abnormalities and joint destruction in a rat inflammatory arthritis model, and two models of post-traumatic OA (PTOA): rat medial meniscal transection (MNX), mouse anterior cruciate ligament (ACL) rupture.
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