Abstract
Models mimicking the realistic geometries and mechanical properties of human tissue are requiring ever-better materials. Biomodels made of poly (vinyl alcohol) are particularly in demand, as they can be used to realistically reproduce the characteristics of blood vessels. The reproducibility of biomodels can be altered due to dehydration that is observed after long periods of usage. In order to improve their usability, one should consider the method used to reproduce them; however, few studies have reported a method reproduce biomodels. This study proposes a novel reproduction method for biomodels that allows them to quickly and easily reproduce their geometric and mechanical properties. Specimens of the dried biomodels were reformed through immersion in temperature-controlled water. Our results show that water at 35 °C can be effective to reproduce both the geometric and mechanical properties of the specimens. X-ray diffraction (XRD) measurements revealed that water immersion can reform the crystal structure of the pre-dried specimens, and images obtained using micro-computed tomography acquisition show that the geometry of the specimens can be reformed by water immersion without introducing any defects. These results indicate that the proposed method can lead to high reproducibility of both the original geometric and mechanical properties of the dried biomodels.
Highlights
Interventional treatments have become much more widespread over the last ten years, and this has necessitated the development of appropriate training tools for medical practitioners[1]
In order to meet the requirements for such in vitro models, biomodels made of poly hydrogel (PVA-H) materials have been developed; this is because poly (vinyl alcohol) hydrogel (PVA-H) can be used to closely resemble both the geometries and mechanical properties of human tissue[4,5,6]
A simple reproduction method was developed for the PVA-H blood vessel biomodels
Summary
Interventional treatments have become much more widespread over the last ten years, and this has necessitated the development of appropriate training tools for medical practitioners[1]. In order to meet the requirements for such in vitro models, biomodels made of poly (vinyl alcohol) hydrogel (PVA-H) materials have been developed; this is because PVA-H can be used to closely resemble both the geometries and mechanical properties of human tissue[4,5,6]. The fabrication method chosen for producing such models should be able to reproduce the mechanical properties and geometries of human tissue as closely as possible, and its fabrication time should be short, so that a lot of models can be made. In order to prevent this from occurring, PVA-H should be usually preserved with submerged it on a preservative liquid These preservation methods require the strict control of storage and treatment conditions while ensuring that the conditions in the hydrogel, such as the water content, do not change. A method is required to represent the geometry and the mechanical properties of realistic blood vessels while the models are being used
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