Abstract
The sinoatrial node (SAN) is the natural pacemaker of the mammalian heart. It has been the the subject of several mathematical studies, aimed at reproducing its electrical response under normal sinus rhythms, as well as under various conditions. Such studies were traditionally done using data from rabbit SAN cells. More recently, human SAN cell data have become available, resulting in the publication of a human SAN cell model (Fabbri et al., 2017), along with its CellML version. Here, we used the CellML file provided by the model authors, together with some SED-ML files and Python scripts that we created to reproduce the main results of the aforementioned modeling study.
Highlights
The sinoatrial node (SAN) plays an important role in cardiac function and it has been extensively studied, some of its intrinsic mechanisms are still open for debate
The CellML file on its own is not sufficient to reproduce all predictions presented in the primary paper
Some SED-ML files (Waltemath et al, 2011) and Python scripts were created and used with the aforementioned CellML file to reproduce the main results from Fabbri et al (2017)
Summary
The sinoatrial node (SAN) plays an important role in cardiac function and it has been extensively studied, some of its intrinsic mechanisms are still open for debate. Most of the experimental data used in SAN modelling have been carried out on animals and on rabbits in particular (Lakatta and DiFrancesco, 2009; DiFrancesco, 2010; Lakatta, 2010; Maltsev and Lakatta, 2010; Noble et al, 2010; Verkerk et al, 2007; Himeno et al, 2008; DiFrancesco and Noble, 2012; Lakatta and Maltsev, 2012; Rosen et al, 2012; Monfredi et al, 2013; Yaniv et al, 2013, 2015) This has resulted in the development of comprehensive SAN models (Wilders, 2007). Verkerk and Wilders (2015) studied the effect of mutations on human SAN cells, highlighting the need for a human-specific SAN cellular electrophysiology model Such a model was formulated by Pohl et al (2016), but its action potential shape does not match that of experimental recordings. No modifications were made to the CellML file mathematics or parameters and all the equations and parameters can be found in the original paper
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