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Abstract

We appreciate your acknowledgement and constructive comments of our study. Our results of the gender-specific development of the internal urethral sphincter demonstrate, at least starting from the second trimester, a significant difference of the muscular volume in this age group. This transitional anatomic difference could be one reason for the so-called functional infravesical obstruction prenatally. This, as a consequence, could be responsible for the higher micturition pressure in male fetuses inducing possible prenatal high-grade vesicoureteral reflux.