Radiation-Induced Sarcoma of the Prostate after Treatment for Rhabdomyosarcoma

Abstract

Rhabdomyosarcoma (RMS) is among the most common pediatric solid malignancies1,2. Fusion-negative, embryonal RMS is the predominant histology among prostate and bladder lesions3. Management strategies depend on clinical stage and risk group. Although the optimal strategy continues to evolve, the field has transitioned from radical upfront resection to organ preservation strategies with multimodal therapy, including chemotherapy, radiation, and surgery. Survivors frequently develop late complications, including impaired fertility and sexual function, bladder dysfunction, and secondary malignancies3–5. Our case describes an 11-year-old male who developed a radiation-induced prostatic sarcoma. We present a novel surgical technique and highlight the importance of multidisciplinary care.