Abstract
Although the study by Komori et al 1 Komori K. Tsujimura A. Miura H. et al. Serial follow-up study of serum testosterone and antisperm antibodies in patients with non-obstructive azoospermia after conventional or microdissection testicular sperm extraction. Int J Androl. 2004; 27: 32-36 Crossref PubMed Scopus (42) Google Scholar reported no change in testosterone after TESE, Ramasamy et al 2 Ramasamy R. Yagan N. Schlegel P.N. Structural and functional changes to the testis after conventional versus microdissection testicular sperm extraction. Urology. 2005; 65: 1190-1194 Abstract Full Text Full Text PDF PubMed Scopus (222) Google Scholar demonstrated a significant decrease in serum testosterone—20%—at 3-6 months. Ramasamy et al also reported that the initial decrease was followed by a return to 95% of the pre-TESE testosterone levels at the end of 18 months. Editorial CommentUrologyVol. 75Issue 3PreviewAlthough the authors did not show any pathologic findings of testis of nonobstuctive azoospermia patients, I guess that many of them might have Kleinfelter's syndrome whose total plasma testosterone levels are decreased in 50%-60% of the patients. Nevertheless, the mean baseline testosterone level 7.83 ng/mL in patients with unsuccessful sperm retrieval looks like to be much higher than that of nonobstructive azoospermia patients seen in the everyday practice. Full-Text PDF
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