Abstract
We thank Cabello et al. (1) for taking the time to offer comments regarding our paper “Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli” (2). We agree that aquaculture is closely associated with the emergence of mobile colistin resistance ( mcr ) genes and have further insights on this hypothesis. To date, eight mobile colistin resistance genes ( mcr-1 to mcr-8 ), as well as several variants, have been characterized, mainly in Enterobacteriaceae from animals, humans, and the environment (3, 4). However, there is strong evidence supporting the hypothesis that these mcr determinants originated from aquatic environments. First, mcr genes …
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