Abstract
We would like to thank Jon Brock for his letter (1) highlighting the importance of delineating causal links between brain connectivity and cognitive function in children with autism spectrum disorders (ASDs). In particular, Brock discusses the challenge of identifying meaningful links between brain connectivity and cognition given the complexity of brain systems and the heterogeneity of behavioral characteristics associated with ASD. We agree that further studies are required to clarify the nature of these brain–behavior relationships in individuals with ASD using targeted functional MRI task paradigms and behavioral measures to further assess reward attribution to speech. Given that brain connections are built and modified throughout development (2), longitudinal studies of children with ASD will also be necessary to better understand the ontogeny of these neural systems. Our current work sheds new light on these issues.
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