Abstract
The replication of φX174 is initiated by conversion of single-stranded ring DNA (SS) into a double-stranded replicative form (RF) DNA molecule. The fact that this conversion of SS to RF is insensitive to high concentration of chloramphenicol suggests involvement of pre-existing host enzyme(s) in this step. The product of a viral gene is required only for the next stage in which the RF replicates to yield further RF (Sinsheimer, 1968).
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