Abstract
The doubling of genomic DNA during the S-phase of the cell cycle involves the global remodeling of chromatin at replication forks. The present review focuses on the eviction of nucleosomes in front of the replication forks to facilitate the passage of replication machinery and the mechanism of replication-coupled chromatin assembly behind the replication forks. The recycling of parental histones as well as the nuclear import and the assembly of newly synthesized histones are also discussed with regard to the epigenetic inheritance.
Highlights
IntroductionThe doubling of genomic DNA occurring in the S-phase involves a timely regulated remodeling of the entire chromatin
In the present overview of chromatin remodeling associated with replication, we pinpointed some concerns that have been the focus of extensive research over the past few decades
This leads researchers to revisit basic questions of chromatin replication for improving our knowledge, even though the basic chromatin subunit assembled behind the replication fork is a mixture of new and parental histones, which remains elusive
Summary
The doubling of genomic DNA occurring in the S-phase involves a timely regulated remodeling of the entire chromatin. Even though the core histone tail modifications directly affect the chromatin activities, most modifications are not exclusive and require a combinatorial set of post-translational modifications for revealing. 2021, 22, 1113 the core histone tail modifications directly affect the chromatin activities, most modifica of 11 tions are not exclusive and require a combinatorial set of post-translational modifications for revealing biological functions, which led to the proposal that the post-translational modifications of core histones might constitute an epigenetic code [13,16]. The core biological functions, which led to the proposal that the post-translational modifications histone tail domains are critical regulators of chromatin activities.
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