Abstract
Huntington’s disease (HD) is a rare genetic disorder resulting in progressive neurodegeneration leading to motor, cognitive and psychiatric symptoms. A high percentage of HD patients suffer from comorbid major depressive disorder (MDD). We are not aware of any literature on the use of repetitive transcranial magnetic stimulation (rTMS) for treating comorbid MDD in HD. We present the case of a 57-year-old man suffering from HD in which comorbid MDD was successfully treated with rTMS. Further work is required to better characterize the safety, tolerability and effectiveness of rTMS to treat comorbid MDD in HD.
Highlights
Huntington’s disease (HD) is a rare neurodegenerative condition usually caused by an inherited genetic mutation in the huntingtin gene
We are not aware of any reports on the use of repetitive transcranial magnetic stimulation (rTMS) in HD patients tients suffering from comorbid major depressive disorder (MDD)
We report on the first demonstration of safe and successful treatment of MDD in a HD patient with rTMS
Summary
Clémence Noiseux 1,† , Jean-Philippe Miron 1, *,† , Véronique Desbeaumes Jodoin 1 , Tian Ren Chu 1 , Sylvain Chouinard 2 and Paul Lespérance 1.
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