Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy (ePIPAC) with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a Dutch, multicentre, open-label, single-arm, phase II study (CRC-PIPAC)

Koen P Rovers ,Harm J Scholten ,Maartje Los,Simon W Nienhuijs ,Anna M.j Thijs ,Clément J.r Huysentruyt ,Emma Wassenaar ,Remond J.a Fijneman ,Marinus J Wiezer ,Rudaba Tajzai,Djamila Boerma,Joost Nederend,Alexander Constantinides,Jacobus W A Burger ,Iris Van ’T Erve ,Maarten J Deenen ,Geert Jan Creemers ,Thomas J.m Kootstra ,Robin J Lurvink ,Onno Kranenburg,Max J Lahaye ,Ignace H J T De Hingh

doi:10.1136/bmjopen-2019-030408

Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy (ePIPAC) with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a Dutch, multicentre, open-label, single-arm, phase II study (CRC-PIPAC)

Koen P Rovers , Harm J Scholten + Show 20 more

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Journal: BMJ Open	Publication Date: Jul 1, 2019
Citations: 22	License type: open-access

Affiliation: Radboud University Nijmegen, Catharina Ziekenhuis, St. Antonius Ziekenhuis, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, University Medical Center Utrecht, Cancer Genomics Centre, Oncode Institute, Maastricht University

#Unresectable Peritoneal Metastases #Colorectal Peritoneal Metastases #Peritoneal Metastases #Treatment Of Colorectal Peritoneal Metastases #Symptoms Of Gastrointestinal Obstruction #Body Surface Area #Pharmacokinetics Of Oxaliplatin #Peer-reviewed Medical Journals #Intravenous Leucovorin #Appendiceal Carcinoma

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IntroductionRepetitive electrostatic pressurised intraperitoneal aerosol chemotherapy with oxaliplatin (ePIPAC-OX) is offered as a palliative treatment option for patients with isolated unresectable colorectal peritoneal metastases (PM) in several centres worldwide. However,...

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Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy (ePIPAC) with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a Dutch, multicentre, open-label, single-arm, phase II study (CRC-PIPAC)