Abstract
PurposeTo investigate the intravisit repeatability of optical coherence tomography angiography (OCTA) in a cohort of uveitis patients.MethodsOne hundred ten patients were imaged twice per eye, per visit, using the Zeiss Cirrus HD-OCT Model 5000 device. To calculate choriocapillaris flow void area (CC FV) 6 × 6-mm images were used, and 3 × 3-mm images were used to calculate vessel density (VD) and the foveal avascular zone area (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Repeatability was measured using Bland-Altman analyses and intraclass correlation coefficients (ICC) with associated coefficient of variation (CV).ResultsThe level of intravisit repeatability differed across indices ranging from moderate to excellent. CC FV had the highest intravisit repeatability with an ICC of 0.980 (95%CI, 0.966–0.989), a CV of 15.9% and Bland-Altman limits of agreement from −0.398 to 0.411 mm2. DCP FAZ had the lowest intravisit repeatability with an ICC of 0.677 (95%CI, 0.510–0.796), a CV of 17.4% and Bland-Altman limits of agreement from −0.395 to −0.355 mm2. Intraoperator repeatability was excellent across all indices.ConclusionsThis study demonstrates that OCTA is a reliable tool to quantitatively assess specific indices of vascular structure in uveitis patients with good intravisit repeatability. However, the range of variability for each index should be taken into account when evaluating clinically meaningful changes.Translational RelevanceThe repeatability of the metrics we have described has implications in supporting the development of OCTA-derived quantitative assessments of the retinal and choroidal vasculature in uveitis patients as potential imaging biomarkers.
Highlights
Optical coherence tomography angiography (OCTA) is an emerging noninvasive technology that allows for visualization of flow in retinal and choroidal blood vessels.[1]
Translational Relevance: The repeatability of the metrics we have described has implications in supporting the development of OCTA-derived quantitative assessments of the retinal and choroidal vasculature in uveitis patients as potential imaging biomarkers
Intraclass correlation coefficients (ICC) is computed as ST2/(ST2 þ SE2), where ST2 is variability among subjects and SE2 is measurement variance
Summary
Optical coherence tomography angiography (OCTA) is an emerging noninvasive technology that allows for visualization of flow in retinal and choroidal blood vessels.[1]. OCTA uses the same low-coherence light to identify dynamic structures of the eye, the vasculature.[1] Vasculature here is defined as a dynamic structure because as separate red blood cells move through vessels, consecutive Bscans will produce different signal patterns due to differences in red blood cell location at the time of each scan. This differential scattering is analyzed by the OCTA software to generate a map of the vasculature.[1,20] Built-in segmentation algorithms al-
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