Abstract
BackgroundThe objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones.MethodsForty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing.ResultsThe therapeutic effect in the test group was superior to that in the control group.ConclusionsFascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects.
Highlights
The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones
Treatments of bone defects mainly include grafting with autogenous free bone, vascularized pedicled bone, bone with microvascular anastomosis, and allogeneic, xenogeneic, and synthetic bone
We explored the effect of fascial flap-wrapped allogeneic bone on repair of large segmental tibial defects in rabbits
Summary
The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. Repair of bone defects has focused on vascularized bone grafts from the iliac crest, scapula, rib, and fibula These methods have sure effects for repair of small segmental tibial defects, but for large segmental defects in weight-bearing bones, the deficiencies such as insufficient grafting bone strength, long external fixation time, vascular anastomosis mismatch, and insufficient bone supply still exist [3,4,5,6,7,8,9,10]. Fascial flap-wrapped allogeneic bones with vascular pedicles have been widely used to repair bone defects due to advantages such as abundance of sources, various shapes and sizes, good bioactivity, and biocompatibility
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