Abstract
Human stromal stem cells derived from endometrium (hESCs) are a type of multipotent stromal cells of the proven ability to differentiate into osteogenic lineage. Thus, it was suggested that these cells may be used to repair skeletal defects. In this study, Human ESCs were extracted from female endometrium and harvested. Biomimetic gelatin/apatite (Gel/Ap) scaffolds with and without harvested cells were implanted in a Critical size calvarial defects in the cranial bone of adult male rat. To CT-Scan and Histological studies were performed to investigate the level of bone formation after 8 weeks of surgery. Results confirmed that the treated defects with the bare and hESCs grafted Gel/Ap scaffold showed significant bone formation and maturation in comparison with the control group.
Highlights
Autogrft and allograft transplantation are known as current strategies for the healing of skeletal tissues
Our laboratory has focused on the use of osteogenic ability of the endometrial mesenchymal stem cells for the repair of skeletal defects [3]
The unique ability to regenerate the human endometrium after menstruation, after childbirth, surgery and postmenopausal women receiving hormone replacement therapy suggests that Mesenchymal stromal cells (MSCs) niches in the present tissue are responsible, at least in part, by this process. it is believed that the human endometrium may include a significant number of stem cells that are responsible for endometrium remarkable regeneration ability [7]
Summary
Autogrft and allograft transplantation are known as current strategies for the healing of skeletal tissues. These approaches were successful but they have shown some intrinsic limitations. Limitation in availability, requirement for background operation and potential morbidity are known as clinical problems for the autologous tissue such as bone and bone marrow transplants [1,2]. Our laboratory has focused on the use of osteogenic ability of the endometrial mesenchymal stem cells for the repair of skeletal defects [3]. We and others have shown that menstrual blood, endometrium and fallopian tubes are very rich sources of mesenchymal stem cells and can differentiate into different cell lines in vitro and/or in vivo [5,6].
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