Repair of abdominal wall defect by NormalGEN (ACTM) in rat models

Abstract

Objective To investigate the feasibility and advantages of NormalGEN (ACTM) for abdominal wall repair in rat models compared to polyester surgical patch. Methods NonnalGEN and polyester surgical patch were used to repair the defect in 12 pairs of rats with abdominal wall defect. These 12 pairs,divided into 3 groups were killed alternately on the 2nd,8th and 16th week. The healing of their abdominal wall defects were then analyzed by comparing the rate of wound infection, the complete healing time,the thickness of the healing tissue and pathological changes under the microscopy. Results There was no mortality in the rats which had their defect repaired by NonnalGEN. In polyester surgical patch group,two rats died of infection, and 10 rats were healed up at the end. Conclusion NonnalGEN has a higher bio-compatibility to repair abdominal wall defects compared to polyester surgical patch. Key words: ] Abdominal wall defect; Gastroschisis; Omphalocele; Tissue engineering