Abstract
Tea is one of the most common beverages in the world. Leaves of Camellia sinensis (Black tea) possess antioxidant, renoprotective and antiapoptotic properties. The present study investigates the effect of black tea (Theaceae) infusion on aflatoxin induced renal damage in male mice. Aflatoxin B1 was orally administered at two doses of 750 and 1,500 mg/kg body weight, for 30 days. Then the black tea infusion was administered at a concentration of 2% in drinking water, simultaneously along with aflatoxin. Biochemical and histopathological analysis were done on 31st day of treatment. Aflatoxin treatment caused significant reduction (−17%) in body weight and corresponding increase in relative organ weight (52%). Aflatoxin at higher dose also caused significant increases in activities of alanine aminotransferase (81%), aspartate aminotransferase (55%), acid phosphatase (32%) and serum creatinine levels (58%) with concurrent decrease in alkaline phosphatase (−23%), succinate dehydrogenase (−44%) adenosine triphosphatase (−45%) activities and serum protein content (−19%). Histopathological changes showed that aflatoxin results in massive disorganization of both glomerular and tubular structures. However, black tea infusion significantly restores these damages at both doses. Thus the use of tea as dietary supplements therefore can be beneficial for the prevention of deteriorative effects of xenobiotic agents.
Published Version
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