Abstract
Article Abstract Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text. To the Editor: Having read with great interest the recent JCP article by Aprahamian et al that examined nephrotoxicity in lithium-treated patients with mild cognitive impairment, I would like to make some remarks on this important topic. First, regarding how lithium affects renal function, we know that renal toxicity induced by lithium mainly manifests as nephrogenic diabetes insipidus (NDI) and that risk for its occurrence is influenced by lithium treatment duration, dose, and plasma level. These patients show progressive reduction in urinary concentrating ability that can progress to chronic interstitial nephropathy and permanently impaired renal function.
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