Abstract
We studied renalvein concentrations of prostaglandin E 2(PGE 2) and activity of the renin-angiotensin system i 9 normotensive young men (NT), 17 hypertensive patients with unilateral renal artery stenosis (URS), and 26 patients with essential hypertension (EH) of whom 12 had low renin essential hypertension (LRH). The PGE 2 concentration, plasma renin activity (PRA), and angiotensin II (A II) were measured in the inferior vena cava and were compared with the mean concentration for both renal veins under basal conditions and without pharmacological interference. The renal vein PGE 2 concentrations were higher in NT (p<0.01) and URS (p<0.05) than in LRH. However, there were no significant differences in A II concentrations between the groups, nor were there any correlations to PGE 2 concentrations. The positive correlation between PRA and PGE 2 (r=0.29, p<0.02) indicates that PGE 2 may contribute to the activation of the renin-angiotensin system or that there may be a common mechanism for stimulation of both hormonal systems. Our results are not compatible with the hypothesis that a reduction of PGE 2 production is a specific feature of patients with EH.
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