Abstract
Concurrent primary failures of adrenocortical and posterior hypophyseal functions, with coincident syndromes of diabetes insipidus and Addison's disease, to our knowledge, have not been described heretofore. The case reported here has clinical interest, therefore, in that the concurrence is uncommon. It also has physiologic interest, in that the defects of water excretion characteristic of the two syndromes are, in some respects, disparate. These renal dysfunctions were demonstrated in our patient and the effects thereon of adrenocortical (hydrocortisone) and posterior hypophyseal (vasopressin (Pitressin)) hormones were determined. The data make it seem unlikely that the adrenal hormone has a specific action on renal tubular reabsorption of water.
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