Abstract
There is a large body of evidence to indicate that adrenal steroids decrease distal renal tubular reabsorption of water. A popular view is that this effect may be due to antagonism of the action of vasopressin on the renal tubules (1), but others (2) have postulated that corticoids may exert a direct effect on permeability of the renal tubular cells to water. Recent studies in patients with combined anterior and posterior pituitary insufficiency (3) suggested that adrenal steroids increase free water excretion by suppressing release of vasopressin from hypothalamic portions of the neurohypophysis. Further investigation of this preliminary hypothesis in normal subjects and in patients with Addison's disease forms the basis of this report.'
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