Abstract
1. 1. Renal clearance experiments were performed in alligators and the effects of acetazolamide studied. 2. 2. The intravenous administration of acetazolamide caused a 40% decrease in blood lactate with no other major systemic change. Ammonium and bicarbonate excretion fell in an inverse relation to that of sodium and chloride. 3. 3. Net renal secretion of bicarbonate was demonstrated, and the alligators recovered from carbonic anhydrase inhibition within a week. 4. 4. It is concluded that renal bicarbonate secretion is intimately related with intracellular carbonic anhydrase activity and chloride reabsorption. These events occur as if they were mirror images of those that take place across parietal cell membranes of mammalian stomach.
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