Abstract
IntroductionIncreasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction. However, the association of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced renal dysfunction with prognosis remains obscure.Materials and methodsAll 154 patients with COVID-19 were recruited from the Second People’s Hospital of Fuyang City in Anhui, China. Demographic characteristics and laboratory data were extracted. Renal dysfunction was evaluated and its prognosis was followed up based on a retrospective cohort study.ResultsThere were 125 (81.2%) mild and 29 (18.8%) severe cases in 154 COVID-19 patients. On admission, 16 (10.4%) subjects were accompanied with renal dysfunction. Serum creatinine and cystatin C were increased and estimated glomerular filtration rate (eGFR) was decreased in severe patients compared with those in mild patients. Renal dysfunction was more prevalent in severe patients. Using multivariate logistic regression, we found that male gender, older age and hypertension were three importantly independent risk factors for renal dysfunction in COVID-19 patients. Follow-up study found that at least one renal function marker of 3.33% patients remained abnormal in 2 weeks after discharge.ConclusionMale elderly COVID-19 patients with hypertension elevates the risk of renal dysfunction. SARS-CoV-2-induced renal dysfunction are not fully recovered in 2 weeks after discharge.
Highlights
Increasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction
We found that male gender, older age and hypertension were three importantly independent risk factors for renal dysfunction in COVID-19 patients
Male elderly COVID-19 patients with hypertension elevates the risk of renal dysfunction
Summary
Increasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction. At the winter of 2019, Coronavirus Disease 2019 (COVID-19), an emerging infectious disease with unclear etiology broke out in Wuhan City, Hubei Province, China [1]. Later, this unknown virus was clarified and named as severe acute respiratory syndrome coronaviruse-2 (SARS-CoV-2) [2, 3]. Xiang et al BMC Infectious Diseases (2021) 21:158 confirmed that SARS-CoV-2 evoked severe acute respiratory syndrome, and induced multiple organ injuries, such as myocardial injury, lymphocyte reduction and even liver dysfunction [8,9,10,11]. The clinical significance of SARS-CoV-2-induced renal dysfunction and its recovery situation are still ambiguous
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