Abstract
Renal Denervation for Resistant Hypertension: Time to Improve Patient Selection. The Lesson From ADPKD
Highlights
Hypertension is one of the most relevant causes of cardiovascular and renal morbidity and mortality worldwide
As the renal nerve plexus plays a central role in regulating arterial blood pressure and renal sympathetic hyperactivity is a major driver of resistant hypertension, minimally-invasive catheter based renal sympathetic ablation has been proposed as an alternative treatment for resistant hypertension, but the results of clinical study remains ambiguous
Blankestijn and Meijvis commented the results of SPYRAL HTN prospective, randomized controlled trial providing evidence of the safety and efficacy of catheter based renal denervation (RD) in unmedicated patients, inserting itself in a long discussion in which hope and disappointment alternated about the safety and efficacy of this method [1]
Summary
Hypertension is one of the most relevant causes of cardiovascular and renal morbidity and mortality worldwide. As the renal nerve plexus plays a central role in regulating arterial blood pressure and renal sympathetic hyperactivity is a major driver of resistant hypertension, minimally-invasive catheter based renal sympathetic ablation (renal denervation) has been proposed as an alternative treatment for resistant hypertension, but the results of clinical study remains ambiguous.
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