Abstract
In The Lancet, Deepak L Bhatt and colleagues report long-term outcomes of renal artery denervation in patients denervated by single-electrode radiofrequency within the SYMPLICITY HTN-3 study. 1 Bhatt DL Vaduganathan M Kandzari DE et al. Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial. Lancet. 2022; (published online Sept 18.)https://doi.org/10.1016/S0140-6736(22)01787-1 Summary Full Text Full Text PDF Scopus (2) Google Scholar This large sham-controlled trial recruited 535 patients (210 [39%] women and 325 [61%] men; mean age in renal denervation group 57·9 years [SD 10·4]) with treatment-resistant hypertension enrolled in 88 centres in the USA. The trial was expected to provide definitive evidence of the efficacy of renal denervation in patients with treatment-resistant hypertension but did not meet its primary 6-month efficacy endpoint, 2 Bhatt DL Kandzari DE O'Neill WW et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014; 370: 1393-1401 Crossref PubMed Scopus (1592) Google Scholar raising an unprecedented wave of scepticism about renal denervation. 3 Persu A Jin Y Fadl Elmula FE Jacobs L Renkin J Kjeldsen S Renal denervation after Symplicity HTN-3: an update. Curr Hypertens Rep. 2014; 16: 460 Crossref PubMed Scopus (29) Google Scholar Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 TrialThis final report of the SYMPLICITY HTN-3 trial adds to the totality of evidence supporting the safety of renal artery denervation to 36 months after the procedure. From 12 months to 36 months after the procedure, patients who were originally randomly assigned to receive renal artery denervation had larger reductions in blood pressure and better blood pressure control compared with patients who received sham control. Full-Text PDF
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