Abstract
Sepsis-induced acute kidney injury (SAKI) is traditionally viewed as aprocess driven by a reduced blood flow and prone tobenefit from vasopressive support. In ovine hyperdynamic septicshock, Lankadeva etal. report a significant and flow-independent intrarenal perfusion and oxygenation "mismatch" jeopardizing the renal medulla that was aggravated by norepinephrine. Medullary and urinary oxygenation changed in parallel, suggesting that urinary oxygenation may act as a biomarker to predictSAKI.
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