Abstract

This article examined the biological removal of high concentrated sulfamethazine (SMZ) antibiotics by the acclimatized activated sludge in lab-scale SBRs system. The removal of SMZ was characterized by a quick adsorption and a slow process of biodegradation. The adsorption capacity of activated sludge for SMZ was 44 and 47 µg SMZ/g SS, respectively, with the initial SMZ concentrations of 1 and 2 mg/L. The adsorption process fitted pseudo-second-order kinetic model. In a series of batch studies, with the increase of initial SMZ concentration that were 1, 2, 3, 5, 7 and 9 mg/L, 56.0%, 51.3%, 42.2%, 29.5%, 25.0% and 20.8% of influent SMZ were biodegraded within 24 h of biological reaction, respectively. The Monod equation applied to simulate SMZ biodegradation had a good coefficient of determination (R2 > 0.99). Furthermore, the results of HPLC demonstrated that the SMZ was not completely removed by the acclimatized activated sludge. From the analysis of LC-MS, 4 intermediates of SMZ biodegradation were identified: Sulfanilic Acid, 4-amino-N-(4,6-dimethyl-2 pyrimidin) benzene sulfonamide, N-(4,6-dimethyl-2-pyrimidin)-4-N-(benzene sulfonamide) benzene sulfonamide, N-(4,6-dimethyl-2-pyrimidin)-4-N-(4,6-dimethyl pyrimidine) benzene sulfonamide, and N-(4,6-dimethyl-2-pyrimidin)-4-N-(3-dimethyl-4-N sodium benzene sulfonamide) benzene sulfonamide.

Highlights

  • The environmental impact of residual pharmaceuticals and personal-care products (PPCPs) has become public concern due to their widespread occurrence in the environment (Gobel et al, 2005; McClellan & Halden, 2010; Vasiliadou et al, 2013)

  • Where k1 is the pseudo-first-order rate constant of adsorption, qe and qt are the amounts of SMZ adsorbed at equilibrium and time t, respectively

  • Qt = k2q2e + qe t where k2 is the pseudo-second-order rate constant of adsorption (g/(mg · min)), qe and qt are the amount of SMZ adsorbed at equilibrium and time t, respectively

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Summary

Introduction

The environmental impact of residual pharmaceuticals and personal-care products (PPCPs) has become public concern due to their widespread occurrence in the environment (Gobel et al, 2005; McClellan & Halden, 2010; Vasiliadou et al, 2013). Among these emerging contaminants, antibiotics are extensively used in human and veterinary medicine and as growth promoting agents in the modern farming and aquaculture industry (Garcia-Galan et al, 2011; Zhou et al, 2014). It is urgent and critical to develop an economical and reliable method for elimination of antibiotics in water and wastewater

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