Abstract
Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.
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