Abstract
Highly conserved orthologous proteins are easily identified by sequence homology alone, whereas poorly conserved orthologs require additional structural information to be identified. All Drosophila orthologs of RNA polymerase I, II, and III subunits-except one-have been identified by sequence homology. Here, we identified CG11076 as the missing Rpa34/POLR1G ortholog in Drosophila . Remote homology detection and secondary structure analysis showed that CG11076 is predicted to have high structural conservation with Rpa34/POLR1G, and phylogenetic analysis demonstrated that these proteins are closely related. Our work underscores the importance of utilizing both sequence and structure to identify highly divergent orthologous proteins in different species.
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