Abstract
Cell Biology Activation of the chemokine receptor CXCR4 by its ligand CXCL12 enables cancer cells to disseminate and metastasize. Spinosa et al. analyzed signaling responses mediated by CXCR4 at the single-cell level. They found that exposing cells to different growth-promoting stimuli before CXCL12 exposure biased CXCR4 signaling through either of its downstream kinases, Akt or ERK. Furthermore, kinase inhibitors that are used to treat cancer increased the likelihood of CXCR4 activation of Akt and/or ERK. Thus, such drugs may inadvertently promote prometastatic CXCR4 signaling. Sci. Signal. 12 , eaaw4204 (2019).
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