Abstract
This chapter presents remarks concerning sulfhydryl protection against radiation injury. There is considerable evidence that protection against radiation effects by sulfhydryl substances is a fairly general phenomenon and that both destructive and regenerative processes may be modified under these conditions. Cysteine and other sulfhydryl substances have been shown to diminish many of the effects of gamma or X-irradiation. The uniformity of protection by cysteine against a number of radiation sequelae in the intact animal points to a true dose reduction in the sense that it alters a common pathway. This suggests that the decisive action occurs at an early stage in the chain of events but does not necessarily imply protection against all radiation changes.
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