Abstract
Some issues, such as the removing of air bubbles from bonding interface, microchannel clogging by adhesive, the methods to increase bonding efficiency, as well as the adhesive bonding of a multilayer chip, still limit the use of adhesive bonding in the mass fabrication of microfluidic devices. In this work, an automatic adhesive bonding machine is developed which can obviously increase bonding efficiency and quality as compared with the traditional manually methods. A bonding method which uses a soft pressing head to extrude the air bubbles from bonding interface is presented. The relationship between the adhesive film thickness and the channel clogging is investigated. The adhesive bonding of three types of two-layer microfluidic devices and a five-layer microfluidic device are studied. Results have shown that the uses of the soft pressing head can effectively removing the air bubbles from the bonding interface. The bonding ratios of all devices are above 95%. The channel residual depth, which is the channel depth excluding the protrusion height of the adhesive film within the channel, will increase to follow the increase in microchannel width and adhesive film thickness.
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