Abstract
Objective To evaluate the reliability and validity of Chinese Mandarin Version of MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR) in patients with schizophrenia. Methods MacCAT-CR was translated into mandarin Chinese with the permission of authors. Inter-rater reliability was assessed by administering the MacCAT-CR to the same patients by 10 independent raters on the same day. The test-retest reliability was assessed in 41 schizophrenia patients between 7 days. Criterion validity analysis was performed by assessing Expert Commence Rating in 100 patients. Construct validity analysis used principal component analysis in the patient group. Discriminant validity was evaluated between patients and controls. Results (1) Inter-rater reliability was 0.989 (P<0.01). The coefficient of inter-item consistency (Cronbach′s α) was 0.868, and the Guttman split half reliability was 0.803. Test-retest reliability of MacCAT-CR was 0.975 (P<0.01). (2) Severity of item scores in MacCAT-CR were correlated with each other (r=0.21-0.78). The total scores of MacCAT-CR and three subparts were individually correlated with ECR significantly (r=0.51-0.87, all P<0.01). Correlation Coefficients were 0.87, 0.79, 0.70 and 0.51 (P<0.01) among the 4 subparts and ECR scores. Factor analysis indicated that MacCAT-CR was consisted of 4 factors counting for 61.03% of variance. Conclusion The Chinese mandarin version of MacCAT-CR has good reliability and validity, worthy of using in clinical new drug trials. Key words: Schizophrenia; Reproducibility of results; MacArthur Competence Assessment Tool for Clinical Research
Published Version
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