Abstract
In vitro dissolution patterns of some spray-congealed products of sulfaethylthiadiazole-wax made into compressed tablets are reported. The tablets were made with a Carver laboratory press, employing a single force of compression and being approximately the same weight. The rate of release of sulfaethylthiadiazole (SETD) from the tablets was evaluated in acid pepsin medium and alkaline pancreatin medium using a rotating-bottle method. There was a gradual decrease in the amount of SETD released from the tablets as the concentration of sorbitan monooleate increased in the formulation, using acid pepsin medium. In alkaline pancreatin medium, an increase in the percentage of SETD released was noted as the concentration of surfactant increased. The mechanism of release of SETD appeared to be due to erosion, solubilization, and leaching of the drug from the tablet. The Higuchi model for drug release from inert matrices could describe the release pattern only for the initial few hours when apparently the variables other than the amount of drug released and time were essentially constant.
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