Release studies of the anticancer drug 5-fluorouracil from chitosan-banana peel extract films

Abstract

5-F-lourouracil is an anticancer drug used for the treatment of different types of cancers. 5-flourouracil loaded chitosan-banana peel extract films were prepared for the in vitro drug release studies. Solvent casting technique was employed to prepare the films. The structure and morphology of the prepared films were analysed by FTIR, XRD and SEM methods and confirmed the presence of drug in the films. The drug loaded films show excellent thermal stability and good shelf life. Studies revealed that the percentage of banana peel extract influences the swelling properties of the film, thickness of the films and release of the drug from the films. Increase in the concentration of chitosan and banana peel extract decreases the swelling properties of the film and rate of release of the drug from the film. The release rate of 5-fluorouracil from the drug loaded chitosan-banana peel extract films were followed spectrophotometrically at λmax 266 nm and the film derived from 1 % chitosan solution and 1 mL aqueous banana peel extract (saturated) exhibited maximum drug release. Cytotoxicity studies proved that the films are non-toxic in nature and augurs well for their applications as excellent drug delivery systems. Antimicrobial studies show that the drug loaded chitosan-banana peel extract films were found to be active against microbes E. coli, Streptococcus mutans, Staphylococcus aureus, Candida albicans and Aspergillus niger and inactive against Pseudomonas aeruginosa.