ANTIOXIDANT ACTIVITY OF COMBINATION BANANA PEEL (MUSA PARADISIACA) AND WATERMELON RIND (CITRULLUS VULGARIS) EXTRACT IN LOTION DOSAGE FORM

Abstract

ABSTRACTObjective: Test the antioxidant activity of banana peel extract, watermelon rind extract, and combinations, also in lotion dosage form.Methods: The antioxidant activity of each extract and their combinations were tested with 2,2-diphenyl-1-picrylhydrazil method and formulated intoa lotion dosage forms. Evaluation of the lotion dosage forms, including organoleptic, homogeneity, pH, viscosity and rheology, microbiology, acutedermal irritation test, as well as the antioxidant activity test.Results: Antioxidant activity test on the extract showed inhibitory concentration 50% (IC50) values of banana peel is 64.03 part per million (ppm)and watermelon rind extract of 300.12 ppm. Combination of banana peel and watermelon rind extract with three different concentrations, IC50:IC50,inhibitory concentration at 75% (IC75):inhibitory concentration at 25% (IC25), IC25:IC75 resulted the best antioxidant activity is a combination of bananapeel, and watermelon rind extract IC75:IC25 with IC50 value of 177.56 ppm. The antioxidant activity test in lotion dosage form showed IC50 values oflotion base is 853.16 ppm, lotion banana peel extract is 472.50 ppm, lotion watermelon rind extract is 496.71 ppm, and the combination of bananapeel and watermelon rind extract are 300.04 ppm.Conclusion: Lotion dosage form formula that meets the requirements of quality, efficacy, and safety with the best antioxidant activity is lotion dosageform combination of banana peel and watermelon rind extract formula (IC75:IC25).Keywords: Antioxidant activity, Banana peel (Musa paradisiaca), Watermelon rind (Citrullus vulgaris), Combination of banana peel and watermelonrind extract, Lotion of antioxidant.