Abstract
Thyroid stimulating hormone (TSH) has been identified in the hypothalamus and other brain areas of the rat. However, the alteration of the release of brain TSH has not been demonstrated. Therefore, we examined the release of immunoreactive TSH (IR-TSH) in vitro from hypothalamic tissue obtained from hypophysectomized, thyroidectomized and intact control rats. Whereas TRH (10(-5) M) and PGE2 (10(-4) M) did not alter hypothalamic IR-TSH release, depolarizing concentrations of potassium (60 mM) or veratridine (5 mM) stimulated the release of IR-TSH from hypothalamic tissue from all groups. These data suggest that IR-TSH synthesized in the hypothalamus is stored in a releasable form.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
