Abstract
Publisher Summary This chapter discusses a study to analyze the release of endogenous amino acids from rabbit superior colliculus (SC). The evoked release of endogenous amino acids from SC slices was monitored in a superfusion system. The analytical set-up was a HPLC-system coupled to a fluorescence detector. By precolumn derivatization with o -phthaldialdehyde (OPT), small amounts of amino acids from perfusates of SC-tissue could be detected. It was shown that glutamate, GABA, and β-alanine are released in a Ca-dependent manner during depolarization with high K + (56 mM). The glutamate release probably is related to the terminals from the visual cortex and the GABA release probably to the interneurons in the SC. Veratridine appeared less specific than high K + for amino acid release and its action was less dependent on the presence of Ca ions.
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